EC 3.4.21.60 - Scutelarin

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ENZYME: 3.4.21.60


ID   3.4.21.60
DE   Scutelarin.
AN   Taipan activator.
CA   Selective cleavage of Arg-|-Thr and Arg-|-Ile in prothrombin to form
CA   thrombin and two inactive fragments.
CC   -!- From the venom of the Taipan snake (Oxyuranus scutellatus).
CC   -!- Converts prothrombin to thrombin.
CC   -!- Specificity is similar to that of Factor Xa (EC 3.4.21.6).
CC   -!- However, unlike Factor Xa this enzyme can cleave its target in the
CC       absence of coagulation Factor Va.
CC   -!- Activity is potentiated by phospholipid and Ca(2+) which binds via
CC       gamma-carboxyglutamic acid residues.
CC   -!- Similar enzymes are known from the venom of other Australian elapid
CC       snakes, including Pseudonaja textilis textilis, Oxyuranus
CC       microlepidotus and Demansia nuchalis affinis.
CC   -!- Formerly EC 3.4.99.28.
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