EC 2.5.1.94 - Adenosyl-chloride synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.94

Names

Accepted name:
adenosyl-chloride synthase
Other names:
chlorinase
5'-chloro-5'-deoxyadenosine synthase
Systematic name:
S-adenosyl-L-methionine:chloride adenosyltransferase

Reaction

Comments:

This enzyme, isolated from the marine bacterium Salinispora tropica, catalyses an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. The enzyme is very similar to EC 2.5.1.63, adenosyl-fluoride synthase, but does not accept fluoride.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Eustaquio, A. S., Pojer, F., Noel, J. P., Moore, B. S.
    Discovery and characterization of a marine bacterial SAM-dependent chlorinase.
    Nat. Chem. Biol. 4: 69-74 (2008). [PMID: 18059261]

[EC 2.5.1.94 created 2010]