EC 2.4.1.252 - GDP-mannose:cellobiosyl-diphosphopolyprenol α-mannosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.252

Names

Accepted name:
GDP-mannose:cellobiosyl-diphosphopolyprenol α-mannosyltransferase
Other names:
GumH
AceA
α1,3-mannosyltransferase AceA
Systematic name:
GDP-mannose:D-Glc-β-(1→4)-Glc-α-1-diphosphoundecaprenol 3-α-mannosyltransferase

Reaction

Comments:

In the bacterium Gluconacetobacter xylinus (previously known as Acetobacter xylinum) the enzyme is involved in the biosynthesis of the exopolysaccharide acetan [1]. In Xanthomonas campestris the enzyme is involved in the biosynthesis of the exopolysaccharide xanthan [5].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Geremia, R. A., Roux, M., Ferreiro, D. U., Dauphin-Dubois, R., Lellouch, A. C., Ielpi, L.
    Expression and biochemical characterisation of recombinant AceA, a bacterial α-mannosyltransferase.
    Mol. Gen. Genet. 261: 933-940 (1999). [PMID: 10485283]
  2. Abdian, P. L., Lellouch, A. C., Gautier, C., Ielpi, L., Geremia, R. A.
    Identification of essential amino acids in the bacterial α-mannosyltransferase AceA.
    J. Biol. Chem. 275: 40568-40575 (2000). [PMID: 11001941]
  3. Petroni, E. A., Ielpi, L.
    Isolation and nucleotide sequence of the GDP-mannose:cellobiosyl-diphosphopolyprenol α-mannosyltransferase gene from Acetobacter xylinum.
    J. Bacteriol. 178: 4814-4821 (1996). [PMID: 8759843]
  4. Lellouch, A. C., Watt, G. M., Geremia, R. A., Flitsch, S. L.
    Phytanyl-pyrophosphate-linked substrate for a bacterial α-mannosyltransferase.
    Biochem. Biophys. Res. Commun. 272: 290-292 (2000). [PMID: 10872841]
  5. Katzen, F., Ferreiro, D. U., Oddo, C. G., Ielmini, M. V., Becker, A., Puhler, A., Ielpi, L.
    Xanthomonas campestris pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence.
    J. Bacteriol. 180: 1607-1617 (1998). [PMID: 9537354]

[EC 2.4.1.252 created 2010]