EC 2.8.2.35 - Dermatan 4-sulfotransferase

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IntEnz Enzyme Nomenclature
EC 2.8.2.35

Names

Accepted name:
dermatan 4-sulfotransferase
Other names:
dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase
dermatan-4-sulfotransferase-1
dermatan-4-sulfotransferase 1
D4ST-1
dermatan N-acetylgalactosamine 4-O-sulfotransferase
CHST14 protein
CHST14
Systematic name:
3'-phospho-5'-adenylyl sulfate:[dermatan]-N-acetylgalactosamine 4-sulfotransferase

Reaction

Comments:

The sulfation takes place at the 4-position of N-acetylgalactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAα(1,3)GalNAcβ(1,4) that is flanked by GlcUAβ(1,3)GalNAcβ(1,4) as compared with IdoUAα(1,3)GalNAcβ(1,4) flanked by IdoUAα(1,3)GalNAcβ(1,4) [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Evers, M. R., Xia, G., Kang, H. G., Schachner, M., Baenziger, J. U.
    Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.
    J. Biol. Chem. 276: 36344-36353 (2001). [PMID: 11470797]
  2. Mikami, T., Mizumoto, S., Kago, N., Kitagawa, H., Sugahara, K.
    Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis.
    J. Biol. Chem. 278: 36115-36127 (2003). [PMID: 12847091]
  3. Pacheco, B., Maccarana, M., Malmstrom, A.
    Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate.
    Glycobiology 19: 1197-1203 (2009). [PMID: 19661164]
  4. Mitsunaga, C., Mikami, T., Mizumoto, S., Fukuda, J., Sugahara, K.
    Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases.
    J. Biol. Chem. 281: 18942-18952 (2006). [PMID: 16702220]

[EC 2.8.2.35 created 2010]