EC 2.1.1.185 - 23S rRNA (guanosine2251-2'-O)-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.185

Names

Accepted name:
23S rRNA (guanosine2251-2'-O)-methyltransferase
Other names:
rlmB
yifH
Systematic name:
S-adenosyl-L-methionine:23S rRNA (guanosine2251-2'-O)-methyltransferase

Reaction

Comments:

The enzyme catalyses the methylation of guanosine2251, a modification conserved in the peptidyltransferase domain of 23S rRNA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (37) [show] [UniProt]

References

  1. Lovgren, J. M., Wikstrom, P. M.
    The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli.
    J. Bacteriol. 183: 6957-6960 (2001). [PMID: 11698387]
  2. Michel, G., Sauve, V., Larocque, R., Li, Y., Matte, A., Cygler, M.
    The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot.
    Structure 10: 1303-1315 (2002). [PMID: 12377117]

[EC 2.1.1.185 created 2010]