EC 1.14.11.31 - Thebaine 6-O-demethylase

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IntEnz Enzyme Nomenclature
EC 1.14.11.31

Names

Accepted name:
thebaine 6-O-demethylase
Other name:
T6ODM
Systematic name:
thebaine,2-oxoglutarate:oxygen oxidoreductase (6-O-demethylating)

Reaction

Cofactor

Comments:

Requires Fe2+. Catalyses a step in morphine biosynthesis. The product neopinione spontaneously rearranges to the more stable codeinone. The enzyme also catalyses the 6-O-demethylation of oripavine to morphinone, with lower efficiency.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102804 , GO:0102802
UniProtKB/Swiss-Prot:

References

  1. Hagel, J. M., Facchini, P. J.
    Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy.
    Nat. Chem. Biol. 6: 273-275 (2010). [PMID: 20228795]

[EC 1.14.11.31 created 2010]