EC - Diacetyl reductase [(S)-acetoin forming]

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IntEnz Enzyme Nomenclature


Accepted name:
diacetyl reductase [(S)-acetoin forming]
Other name:
(S)-acetoin dehydrogenase
Systematic name:
(S)-acetoin:NAD+ oxidoreductase



The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC or EC While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the bacteria Geobacillus stearothermophilus, Enterobacter aerogenes and Klebsiella pneumoniae [1-3]. Different from EC, diacetyl reductase [(R)-acetoin forming].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019152 , GO:0052588
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Giovannini, P. P., Medici, A., Bergamini, C. M., Rippa, M.
    Properties of diacetyl (acetoin) reductase from Bacillus stearothermophilus.
    Bioorg. Med. Chem. 4: 1197-1201 (1996). [PMID: 8879540]
  2. Carballo, J., Martin, R., Bernardo, A., Gonzalez, J.
    Purification, characterization and some properties of diacetyl(acetoin) reductase from Enterobacter aerogenes.
    Eur. J. Biochem. 198: 327-332 (1991). [PMID: 2040298]
  3. Ui, S., Okajima, Y., Mimura, A., Kanai, H., Kobayashi, T., Kudo, T.
    Sequence analysis of the gene for and characterization of D-acetoin forming meso-2,3-butanediol dehydrogenase of Klebsiella pneumoniae expressed in Escherichia coli.
    J. Ferment. Bioeng. 83: 32-37 (1997).

[EC created 2010]