EC 1.1.1.304 - Diacetyl reductase [(S)-acetoin forming]

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IntEnz Enzyme Nomenclature
EC 1.1.1.304

Names

Accepted name:
diacetyl reductase [(S)-acetoin forming]
Other name:
(S)-acetoin dehydrogenase
Systematic name:
(S)-acetoin:NAD+ oxidoreductase

Reaction

Comments:

The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the bacteria Geobacillus stearothermophilus, Enterobacter aerogenes and Klebsiella pneumoniae [1-3]. Different from EC 1.1.1.303, diacetyl reductase [(R)-acetoin forming].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019152 , GO:0052588
UniProtKB/Swiss-Prot: (11) [show] [UniProt]

References

  1. Giovannini, P. P., Medici, A., Bergamini, C. M., Rippa, M.
    Properties of diacetyl (acetoin) reductase from Bacillus stearothermophilus.
    Bioorg. Med. Chem. 4: 1197-1201 (1996). [PMID: 8879540]
  2. Carballo, J., Martin, R., Bernardo, A., Gonzalez, J.
    Purification, characterization and some properties of diacetyl(acetoin) reductase from Enterobacter aerogenes.
    Eur. J. Biochem. 198: 327-332 (1991). [PMID: 2040298]
  3. Ui, S., Okajima, Y., Mimura, A., Kanai, H., Kobayashi, T., Kudo, T.
    Sequence analysis of the gene for and characterization of D-acetoin forming meso-2,3-butanediol dehydrogenase of Klebsiella pneumoniae expressed in Escherichia coli.
    J. Ferment. Bioeng. 83: 32-37 (1997).

[EC 1.1.1.304 created 2010]