EC - Diacetyl reductase [(R)-acetoin forming]

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IntEnz Enzyme Nomenclature


Accepted name:
diacetyl reductase [(R)-acetoin forming]
Other name:
(R)-acetoin dehydrogenase
Systematic name:
(R)-acetoin:NAD+ oxidoreductase



The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC or EC While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the yeast Saccharomyces cerevisiae [1,2]. Different from EC, diacetyl reductase [(S)-acetoin forming].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00058
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019152 , GO:0052587
CAS Registry Number: 9028-49-3


  1. Heidlas, J., Tressl, R.
    Purification and characterization of a (R)-2,3-butanediol dehydrogenase from Saccharomyces cerevisiae.
    Arch. Microbiol. 154: 267-273 (1990). [PMID: 2222122]
  2. Gonzalez, E., Fernandez, M. R., Larroy, C., Sola, L., Pericas, M. A., Pares, X., Biosca, J. A.
    Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene.
    J. Biol. Chem. 275: 35876-35885 (2000). [PMID: 10938079]

[EC created 1961 as EC, transferred 2010 to EC]