EC 2.1.1.164 - Demethylrebeccamycin-D-glucose O-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.164

Names

Accepted name:
demethylrebeccamycin-D-glucose O-methyltransferase
Other name:
RebM
Systematic name:
S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase

Reaction

Comments:

Catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is able to use a wide variety substrates, tolerating variation on the imide heterocycle, deoxygenation of the sugar moiety, and even indolocarbazole glycoside anomers [1]. The enzyme is a member of the general acid/base-dependent O-methyltransferase family [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102082
UniProtKB/Swiss-Prot:

References

  1. Zhang, C., Albermann, C., Fu, X., Peters, N. R., Chisholm, J. D., Zhang, G., Gilbert, E. J., Wang, P. G., Van Vranken, D. L., Thorson, J. S.
    RebG- and RebM-catalyzed indolocarbazole diversification.
    Chembiochem 7: 795-804 (2006). [PMID: 16575939]
  2. Singh, S., McCoy, J. G., Zhang, C., Bingman, C. A., Phillips, G. N., Thorson, J. S.
    Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM.
    J. Biol. Chem. 283: 22628-22636 (2008). [PMID: 18502766]

[EC 2.1.1.164 created 2010]