EC - O-phosphoseryl-tRNASec kinase

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IntEnz Enzyme Nomenclature


Accepted name:
O-phosphoseryl-tRNASec kinase
Other names:
phosphoseryl-tRNA[Ser]Sec kinase
phosphoseryl-tRNASec kinase
L-seryl-tRNASec kinase
Systematic name:
ATP:L-seryl-tRNASec O-phosphotransferase



In archaea and eukarya selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by EC (Sep-tRNA:Sec-tRNA synthase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 91273-83-5


  1. Carlson, B. A., Xu, X. M., Kryukov, G. V., Rao, M., Berry, M. J., Gladyshev, V. N., Hatfield, D. L.
    Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.
    Proc. Natl. Acad. Sci. USA 101: 12848-12853 (2004). [PMID: 15317934]
  2. Sherrer, R. L., O'Donoghue, P., Soll, D.
    Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation.
    Nucleic Acids Res. 36: 1247-1259 (2008). [PMID: 18174226]
  3. Khangulov, S. V., Gladyshev, V. N., Dismukes, G. C., Stadtman, T. C.
    Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.
    Biochemistry 37: 3518-3528 (1998). [PMID: 9521673]

[EC created 2009]