EC 2.7.1.163 - Hygromycin B 4-O-kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.163

Names

Accepted name:
hygromycin B 4-O-kinase
Other name:
hygromycin-B kinase [ambiguous]
Systematic name:
ATP:hygromycin-B 4-O-phosphotransferase

Reaction

Comments:

Phosphorylates the antibiotic hygromycin B. Whereas the enzyme from Streptomyces hygroscopicus (EC 2.7.1.119; hygromycin-B 7''-O-kinase) catalyses the formation of 7''-O-phosphohygromycin B, this enzyme, found in Escherichia coli carrying a plasmid conferring resistance to hygromycin-B, forms 4-O-phosphohygromycin B.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Rao, R.N., Allen, N.E., Hobbs, J.N., Jr., Alborn, W.E., Jr., Kirst, H.A., Paschal, J.W.
    Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli.
    Antimicrob. Agents Chemother. 24 : 689-695 (1983). [PMID: 6318654]

[EC 2.7.1.163 created 2009]