EC 5.1.3.23 - UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase

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ENZYME: 5.1.3.23


ID   5.1.3.23
DE   UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase.
AN   2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase.
AN   UDP-alpha-D-GlcNAc3NAcA 2-epimerase.
AN   UDP-GlcNAc3NAcA 2-epimerase.
CA   UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-
CA   diacetamido-2,3-dideoxy-alpha-D-mannuronate.
CC   -!- Participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA
CC       (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid),
CC       an important precursor of the B-band lipopolysaccharide of
CC       Pseudomonas aeroginosa serotype O5 and of the band-A trisaccharide of
CC       Bordetella pertussis, both important respiratory pathogens.
CC   -!- Highly specific as UDP-alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2-
CC       acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D-GlcNAc3NAc
CC       (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucose) cannot act as
CC       substrates.
DR   G3XD61    , WBPI_PSEAE ;
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