EC 2.1.1.162 - Glycine/sarcosine/dimethylglycine N-methyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.1.1.162

Names

Accepted name:
glycine/sarcosine/dimethylglycine N-methyltransferase
Other names:
GSDMT
glycine sarcosine dimethylglycine N-methyltransferase
Systematic name:
S-adenosyl-L-methionine:glycine(or sarcosine or N,N-dimethylglycine) N-methyltransferase [sarcosine(or N,N-dimethylglycine or betaine)-forming]

Reaction

Comments:

Unlike EC 2.1.1.156 (glycine/sarcosine N-methyltransferase), EC 2.1.1.157 (sarcosine/dimethylglycine N-methyltransferase) and EC 2.1.1.161 (dimethylglycine N-methyltransferase), this enzyme, from the halophilic methanoarchaeon Methanohalophilus portucalensis, can methylate glycine and all of its intermediates to form the compatible solute betaine [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052729 , GO:0017174 , GO:0052730

References

  1. Lai, M.-C., Wang, C.-C., Chuang, M.-J., Wu, Y.-C. and Lee, Y.-C.
    Effects of substrate and potassium on the betaine-synthesizing enzyme glycine sarcosine dimethylglycine N-methyltransferase from a halophilic methanoarchaeon Methanohalophilus portucalensis.
    Res. Microbiol. 157: 948-955 (2006). [PMID: 17098399]

[EC 2.1.1.162 created 2007]