EC 2.1.1.161 - Dimethylglycine N-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.161

Names

Accepted name:
dimethylglycine N-methyltransferase
Other names:
BsmB
DMT
Systematic name:
S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase (betaine-forming)

Reaction

Comments:

This enzyme, from the marine cyanobacterium Synechococcus sp. WH8102, differs from EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase in that it cannot use sarcosine as an alternative substrate [1]. Betaine is a 'compatible solute' that enables cyanobacteria to cope with osmotic stress by maintaining a positive cellular turgor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052729
UniProtKB/Swiss-Prot:

References

  1. Lu, W.D., Chi, Z.M. and Su, C.D.
    Identification of glycine betaine as compatible solute in Synechococcus sp. WH8102 and characterization of its N-methyltransferase genes involved in betaine synthesis.
    Arch. Microbiol. 186: 495-506 (2006). [PMID: 17019606]

[EC 2.1.1.161 created 2007]