EC - Diphosphoinositol-pentakisphosphate kinase

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IntEnz Enzyme Nomenclature


Accepted name:
diphosphoinositol-pentakisphosphate kinase
Other names:
ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase
PP-IP5 kinase
diphosphoinositol pentakisphosphate kinase
PP-InsP5 kinase
Systematic name:
ATP:1D-myo-inositol-5-diphosphate-pentakisphosphate phosphotransferase



This enzyme is activated by osmotic shock [4]. Ins(1,3,4,5,6)P5, 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102092 , GO:0033857
UniProtKB/Swiss-Prot: (15) [show] [UniProt]


  1. Shears, S.B., Ali, N., Craxton, A. and Bembenek, M.E.
    Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo.
    J. Biol. Chem. 270: 10489-10497 (1995). [PMID: 7737983]
  2. Albert, C., Safrany, S.T., Bembenek, M.E., Reddy, K.M., Reddy, K.K., Falck, J.-R., Bröcker, M., Shears, S.B. and Mayr, G.W.
    Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.
    Biochem. J. 327: 553-560 (1997). [PMID: 9359429]
  3. Fridy, P.C., Otto, J.C., Dollins, D.E. and York, J.D.
    Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases.
    J. Biol. Chem. 282: 30754-30762 (2007). [PMID: 17690096]
  4. Choi, J.H., Williams, J., Cho, J., Falck, J.R. and Shears, S.B.
    Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress.
    J. Biol. Chem. 282: 30763-30775 (2007). [PMID: 17702752]
  5. Lin, H., Fridy, P. C., Ribeiro, A. A., Choi, J. H., Barma, D. K., Vogel, G., Falck, J. R., Shears, S. B., York, J. D., Mayr, G. W.
    Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.
    J. Biol. Chem. 284: 1863-1872 (2009). [PMID: 18981179]
  6. Wang, H., Falck, J. R., Hall, T. M., Shears, S. B.
    Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
    Nat. Chem. Biol. 8: 111-116 (2012). [PMID: 22119861]

[EC created 2003 as EC, transferred 2007 to EC, modified 2014]