EC 22.214.171.124 - Aldos-2-ulose dehydratase
IntEnz Enzyme Nomenclature
1,5-anhydro-D-fructose dehydratase (microthecin-forming)
12100 [IUBMB]1,5-anhydro-D-fructose1,5-anhydro-D-fructoseName origin: UniProt - CHECKED (C)Formula: C6H10O5
Charge: 0ChEBI compound status: CHECKED (C)=H2OH2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)
This enzyme catalyses two of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. Aldose-2-uloses such as 2-dehydroglucose can also act as substrates, but more slowly [1,2,4]. This is a bifunctional enzyme that acts as both a lyase and as an isomerase . Differs from EC 126.96.36.199, which can carry out only reaction (1a), is inhibited by its product and requires metal ions for activity .
Links to other databases
The anhydrofructose pathway and its possible role in stress response and signaling.Biochim. Biophys. Acta 1760: 1314-1322 (2006). [PMID: 16822618]
Enzymatic description of the anhydrofructose pathway of glycogen degradation II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate.Biochim. Biophys. Acta 1723: 63-73 (2005). [PMID: 15716041]
Presence of microthecin in the red alga Gracilariopsis lemaneiformis and its formation from 1,5-anhydro-D-fructose.Phytochemistry 41: 151-154 (1996).
Pyranosone dehydratase from the basidiomycete Phanerochaete chrysosporium: improved purification, and identification of 6-deoxy-D-glucosone and D-xylosone reaction products.Arch. Microbiol. 160: 27-34 (1993). [PMID: 8352649]
Enzymatic description of the anhydrofructose pathway of glycogen degradation. I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and α-1,4-glucan lyase in the fungus Anthracobia melaloma.Biochim. Biophys. Acta 1672: 120-129 (2004). [PMID: 15110094]
[EC 188.8.131.52 created 2006]