EC 2.7.8.27 - Sphingomyelin synthase

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ENZYME: 2.7.8.27


ID   2.7.8.27
DE   Sphingomyelin synthase.
AN   Phosphatidylcholine:ceramide cholinephosphotransferase.
AN   SM synthase.
CA   A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-
CA   sn-glycerol.
CC   -!- The reaction can occur in both directions.
CC   -!- Occupies a central position in sphingolipid and glycerophospholipid
CC       metabolism.
CC   -!- Up- and down-regulation of its activity has been linked to mitogenic
CC       and pro-apoptotic signaling in a variety of mammalian cell types.
CC   -!- Unlike EC 2.7.8.3 CDP-choline cannot replace phosphatidylcholine as
CC       the donor of the phosphocholine moiety of sphingomyelin.
DR   Q38E55    , SLS3_TRYB2 ;  B3A0M1    , SLS3_TRYBB ;  Q38E56    , SLS4_TRYB2 ;
DR   B3A0M2    , SLS4_TRYBB ;  Q9U3D4    , SMS1_CAEEL ;  Q7T3T4    , SMS1_CHICK ;
DR   Q86VZ5    , SMS1_HUMAN ;  Q8VCQ6    , SMS1_MOUSE ;  A0AAS4    , SMS1_PIG   ;
DR   Q7TSX5    , SMS1_RAT   ;  Q20735    , SMS2_CAEEL ;  Q8NHU3    , SMS2_HUMAN ;
DR   Q4R763    , SMS2_MACFA ;  Q9D4B1    , SMS2_MOUSE ;  Q4JM44    , SMS2_RAT   ;
DR   Q965Q4    , SMS3_CAEEL ;
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