EC - NADH dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
NADH dehydrogenase
Other names:
β-NADH dehydrogenase dinucleotide
DPNH diaphorase
NADH diaphorase
NADH hydrogenase
NADH oxidoreductase
NADH-menadione oxidoreductase
NADH:cytochrome c oxidoreductase
cytochrome c reductase
dihydrocodehydrogenase I dehydrogenase
dihydronicotinamide adenine dinucleotide dehydrogenase
diphosphopyridine diaphorase
reduced diphosphopyridine nucleotide diaphorase
type 1 dehydrogenase
NADH:(acceptor) oxidoreductase
NADH2 dehydrogenase
Systematic name:
NADH:acceptor oxidoreductase




A flavoprotein containing iron-sulfur centres. After preparations have been subjected to certain treatments, cytochrome c may act as an acceptor. Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment. Formerly EC; present in a mitochondrial complex as EC, NADH:ubiquinone reductase (H+-translocating).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00496
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003954
CAS Registry Number: 9079-67-8
UniProtKB/Swiss-Prot: (137) [show] [UniProt]


  1. Adachi, K. and Okuyama, T.
    Study on the reduced pyridine nucleotide dehydrogenase of bovine erythrocytes. I. Crystallization and properties of the reduced pyridine nucleotide dehydrogenase of bovine erythrocytes.
    Biochim. Biophys. Acta 268: 629-637 (1972). [PMID: 4402556]
  2. Hatefi, Y., Ragan, C.I. and Galante, Y.M.
    The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system.
    In: Martonosi, A.N. (Ed.) The Enzymes of Biological Membranes, 2nd ed. vol. 4, Wiley, New York, 1985, 1-70
  3. Hochstein, L.I. and Dalton, B.P.
    Studies of a halophilic NADH dehydrogenase. I. Purification and properties of the enzyme.
    Biochim. Biophys. Acta 302: 216-228 (1973). [PMID: 4144655]
  4. Kaniuga, Z.
    The transformation of mitochondrial NADH dehydrogenase into NADH:Cytochrome c oxidoreductase.
    Biochim. Biophys. Acta 73: 550-564 (1963). [PMID: 14074130]

[EC created 1961 as EC, transferred 1965 to EC, modified 2018]