EC 2.6.1.82 - Putrescine—2-oxoglutarate transaminase

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IntEnz Enzyme Nomenclature
EC 2.6.1.82

Names

Accepted name:
putrescine—2-oxoglutarate transaminase
Other names:
putrescine-α-ketoglutarate transaminase
YgjG
putrescine:α-ketoglutarate aminotransferase
PAT
butane-1,4-diamine:2-oxoglutarate aminotransferase
putrescine transaminase [ambiguous]
putrescine aminotransferase [ambiguous]
Systematic name:
putrescine:2-oxoglutarate aminotransferase

Reaction

Cofactor

Comments:

A pyridoxal 5'-phosphate protein [3]. The product, 4-aminobutanal, spontaneously cyclizes to form 1-pyrroline, which is a substrate for EC 1.2.1.19, aminobutyraldehyde dehydrogenase. Cadaverine and spermidine can also act as substrates [3]. Forms part of the arginine-catabolism pathway [2]. cf. EC 2.6.1.113, putrescine—pyruvate transaminase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00519
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033094
UniProtKB/Swiss-Prot: (47) [show] [UniProt]

References

  1. Prieto-Santos, M.I., Martin-Checa, J., Balana-Fouce, R. and Garrido-Pertierra, A.
    A pathway for putrescine catabolism in Escherichia coli.
    Biochim. Biophys. Acta 880: 242-244 (1986). [PMID: 3510672]
  2. Samsonova, N.N., Smirnov, S.V., Novikova, A.E. and Ptitsyn, L.R.
    Identification of Escherichia coli K12 YdcW protein as a γ-aminobutyraldehyde dehydrogenase.
    FEBS Lett. 579: 4107-4112 (2005). [PMID: 16023116]
  3. Samsonova, N.N., Smirnov, S.V., Altman, I.B. and Ptitsyn, L.R.
    Molecular cloning and characterization of Escherichia coli K12 ygjG gene.
    BMC Microbiol. 3: 2 (2003). [PMID: 12617754]

[EC 2.6.1.82 created 2006, modified 2017]