EC 2.7.1.151 - Inositol-polyphosphate multikinase

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ENZYME: 2.7.1.151


ID   2.7.1.151
DE   Inositol-polyphosphate multikinase.
AN   Inositol polyphosphate 6-/3-/5-kinase.
AN   IP3/IP4 6-/3-kinase.
AN   IP3/IP4 dual-specificity 6-/3-kinase.
AN   IpK2.
CA   2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol
CA   1,3,4,5,6-pentakisphosphate.
CC   -!- This enzyme also phosphorylates Ins(1,4,5)P(3) to Ins(1,3,4,5)P(4),
CC       Ins(1,3,4,5)P(4) to Ins(1,3,4,5,6)P(5), and Ins(1,3,4,5,6)P(4) to
CC       Ins(PP)P(4), isomer unknown.
CC   -!- The enzyme from the plant Arabidopsis thaliana can also phosphorylate
CC       Ins(1,3,4,6)P(4) and Ins(1,2,3,4,6)P(5) at the D-5-position to
CC       produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate
CC       (InsP(6)), respectively.
CC   -!- Yeast produces InsP(6) from Ins(1,4,5)P(3) by the actions of this
CC       enzyme and EC 2.7.1.158.
DR   A2X5H5    , IPK2_ORYSI ;  Q6H545    , IPK2_ORYSJ ;  Q7TT16-2  , IPMK-2_MOUSE;
DR   Q9LY23    , IPMKA_ARATH;  Q9FLT2    , IPMKB_ARATH;  Q8NFU5    , IPMK_HUMAN ;
DR   Q7TT16    , IPMK_MOUSE ;  Q99NI4    , IPMK_RAT   ;  Q9US14    , IPMK_SCHPO ;
DR   P07250    , IPMK_YEAST ;
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