EC - Diaminobutyrate—2-oxoglutarate transaminase

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IntEnz Enzyme Nomenclature


Accepted name:
diaminobutyrate—2-oxoglutarate transaminase
Other names:
2,4-diaminobutyrate 4-aminotransferase
L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase
diaminobutyrate transaminase
DABA aminotransferase
diaminobutyrate—2-oxoglutarate aminotransferase
DAB aminotransferase
diaminibutyric acid aminotransferase
L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase
Systematic name:
L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase




A pyridoxal-phosphate protein that requires potassium for activity [4]. In the proteobacterium Acinetobacter baumannii, this enzyme is a product of the ddc gene that also encodes EC, diaminobutyrate decarboxylase. Differs from EC, diaminobutyrate—pyruvate transaminase, which has pyruvate as the amino-group acceptor. This is the first enzyme in the ectoine-biosynthesis pathway, the other enzymes involved being EC, diaminobutyrate acetyltransferase and EC, ectoine synthase [3,4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00519
Structural data: CSA , EC2PDB
Gene Ontology: GO:0045303
CAS Registry Number: 196622-96-5
UniProtKB/Swiss-Prot: (21) [show] [UniProt]


  1. Ikai, H.and Yamamoto, S.
    Identification and analysis of a gene encoding L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase involved in the 1,3-diaminopropane production pathway in Acinetobacter baumannii.
    J. Bacteriol. 179: 5118-5125 (1997). [PMID: 9260954]
  2. Ikai, H. and Yamamoto, S.
    Two genes involved in the 1,3-diaminopropane production pathway in Haemophilus influenzae.
    Biol. Pharm. Bull. 21: 170-173 (1998). [PMID: 9514614]
  3. Peters, P., Galinski, E.A. and Truper, H.G.
    The biosynthesis of ectoine.
    FEMS Microbiol. Lett. 71: 157-162 (1990).
  4. Ono, H., Sawada, K., Khunajakr, N., Tao, T., Yamamoto, M., Hiramoto, M., Shinmyo, A., Takano, M. and Murooka, Y.
    Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata.
    J. Bacteriol. 181: 91-99 (1999). [PMID: 9864317]
  5. Kuhlmann, A.U. and Bremer, E.
    Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
    Appl. Environ. Microbiol. 68: 772-783 (2002). [PMID: 11823218]
  6. Louis, P. and Galinski, E.A.
    Characterization of genes for the biosynthesis of the compatible solute ectoine from Marinococcus halophilus and osmoregulated expression in Escherichia coli.
    Microbiology 143: 1141-1149 (1997). [PMID: 9141677]

[EC created 2000, modified 2006]