EC 2.7.11.20 - Elongation factor 2 kinase

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IntEnz Enzyme Nomenclature
EC 2.7.11.20

Names

Accepted name:
elongation factor 2 kinase
Other names:
Ca/CaM-kinase III
calmodulin-dependent protein kinase III
CaM kinase III
eEF2 kinase
eEF2K
EF2K
STK19
Systematic name:
ATP:[elongation factor 2] phosphotransferase

Reaction

Cofactor

Comments:

Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC51158
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004686
UniProtKB/Swiss-Prot:

References

  1. Mitsui, K., Brady, M., Palfrey, H.C. and Nairn, A.C.
    Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas.
    J. Biol. Chem. 268: 13422-13433 (1993). [PMID: 8514778]
  2. Hincke, M.T. and Nairn, A.C.
    Phosphorylation of elongation factor 2 during Ca2+-mediated secretion from rat parotid acini.
    Biochem. J. 282: 877-882 (1992). [PMID: 1372803]
  3. Knebel, A., Morrice, N. and Cohen, P.
    A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38δ.
    EMBO J. 20: 4360-4369 (2001). [PMID: 11500363]
  4. Sans, M.D., Xie, Q. and Williams, J.A.
    Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini.
    Biochem. Biophys. Res. Commun. 319: 144-151 (2004). [PMID: 15158453]
  5. Browne, G.J., Finn, S.G. and Proud, C.G.
    Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
    J. Biol. Chem. 279: 12220-12231 (2004). [PMID: 14709557]
  6. Ryazanov, A.G.
    Elongation factor-2 kinase and its newly discovered relatives.
    FEBS Lett. 514: 26-29 (2002). [PMID: 11904175]

[EC 2.7.11.20 created 2005]