EC 2.7.11.19 - Phosphorylase kinase

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ENZYME: 2.7.11.19


ID   2.7.11.19
DE   Phosphorylase kinase.
AN   Dephosphophosphorylase kinase.
AN   Glycogen phosphorylase kinase.
AN   PHK.
AN   Phosphorylase b kinase.
AN   Phosphorylase B kinase.
AN   Phosphorylase kinase (phosphorylating).
CA   2 ATP + phosphorylase b = 2 ADP + phosphorylase a.
CF   Ca(2+).
CC   -!- Requires calmodulin for activity.
CC   -!- The enzyme phosphorylates a specific serine residue in each of the
CC       subunits of the dimeric phosphorylase b.
CC   -!- For muscle phosphorylase but not liver phosphorylase, this is
CC       accompanied by a further dimerization to form a tetrameric
CC       phosphorylase.
CC   -!- The enzyme couples muscle contraction with energy production via
CC       glycogenolysis--glycolysis by catalyzing the Ca(2+)-dependent
CC       phosphorylation and activation of glycogen phosphorylase b.
CC   -!- The gamma subunit of the tetrameric alpha-beta-gamma-delta enzyme is
CC       the catalytic subunit.
CC   -!- Formerly EC 2.7.1.38.
PR   PROSITE; PDOC00100;
DR   Q16816-2  , PHKG1-2_HUMAN;  Q16816    , PHKG1_HUMAN;  P07934    , PHKG1_MOUSE;
DR   P00518    , PHKG1_RABIT;  P13286    , PHKG1_RAT  ;  P15735-2  , PHKG2-2_HUMAN;
DR   Q2KJ16    , PHKG2_BOVIN;  P15735    , PHKG2_HUMAN;  Q9DB30    , PHKG2_MOUSE;
DR   P31325    , PHKG2_RAT  ;
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