EC 2.8.2.34 - Glycochenodeoxycholate sulfotransferase

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IntEnz Enzyme Nomenclature
EC 2.8.2.34

Names

Accepted name:
glycochenodeoxycholate sulfotransferase
Other names:
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase
bile acid:PAPS:sulfotransferase
BAST
Systematic name:
3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase

Reaction

Comments:

The enzyme specifically sulfates glycochenodeoxycholate at the 7α-position (see also EC 2.8.2.14 bile-salt sulfotransferase). The monohydroxy bile acids glycolithocholate, chenodeoxycholate and ursodeoxycholate act as inhibitors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033876

References

  1. Barnes, S., Burhol, P.G., Zander, R., Haggstrom, G., Settine, R.L. and Hirschowitz, B.I.
    Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters.
    J. Lipid Res. 20: 952-959 (1979). [PMID: 533830]
  2. Russell, D.W.
    The enzymes, regulation, and genetics of bile acid synthesis.
    Annu. Rev. Biochem. 72: 137-174 (2003). [PMID: 12543708]

[EC 2.8.2.34 created 2005]