EC - Xanthoxin dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
xanthoxin dehydrogenase
Other names:
xanthoxin oxidase
Systematic name:
xanthoxin:NAD+ oxidoreductase




Requires a molybdenum cofactor for activity. NADP+ cannot replace NAD+ and short-chain alcohols such as ethanol, isopropanol, butanol and cyclohexanol cannot replace xanthoxin as substrate [3]. Involved in the abscisic-acid biosynthesis pathway in plants, along with EC (abscisic aldehyde oxidase), EC (9-cis-epoxycarotenoid dioxygenase) and EC [(+)-abscisic acid 8'-hydroxylase]. Abscisic acid is a sesquiterpenoid plant hormone that is involved in the control of a wide range of essential physiological processes, including seed development, germination and responses to stress [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0010301


  1. Sindhu, R.K. and Walton, D.C.
    Xanthoxin metabolism in cell-free preparations from wild type and wilty mutants of tomato.
    Plant Physiol. 88: 178-182 (1988).
  2. Schwartz, S.H., Léon-Kloosterziel, K.M., Koornneef, M. and Zeevaart, J.A.D.
    Biochemical characterization of the aba2 and aba3 mutants in Arabidopsis thaliana.
    Plant Physiol. 114: 161-166 (1997). [PMID: 9159947]
  3. González-Guzmán, M., Apostolova, N., Bellés, J.M., Barrero, J.M., Piqueras, P., Ponce, M.R., Micol, J.L., Serrano, R. and Rodríguez, P.L.
    The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde.
    Plant Cell 14: 1833-1846 (2002). [PMID: 12172025]

[EC created 2005]