EC - Saccharopine dehydrogenase (NAD+, L-lysine-forming)

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IntEnz Enzyme Nomenclature


Accepted name:
saccharopine dehydrogenase (NAD+, L-lysine-forming)
Other names:
N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)
ε-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)
lysine-2-oxoglutarate reductase
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
Systematic name:
N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004754
CAS Registry Number: 9073-96-5


  1. Fujioka, M. and Nakatani, Y.
    Saccharopine dehydrogenase. Interaction with substrate analogues.
    Eur. J. Biochem. 25: 301-307 (1972). [PMID: 4339117]
  2. Saunders, P.P. and Broquist, H.P.
    Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase.
    J. Biol. Chem. 241: 3435-3440 (1966). [PMID: 4287986]

[EC created 1972]