EC 3.5.1.91 - N-substituted formamide deformylase

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IntEnz Enzyme Nomenclature
EC 3.5.1.91

Names

Accepted name:
N-substituted formamide deformylase
Other name:
NfdA
Systematic name:
N-benzylformamide amidohydrolase

Reaction

Cofactor

Comments:

Zinc is a cofactor. While N-benzylformamide is the best substrate, the enzyme from Arthrobacter pascens can also act on the N-substituted formamides N-butylformamide, N-allylformamide, N-[2-(cyclohex-1-enyl)ethyl]formamide and N-(1-phenylethyl)formamide, but much more slowly. Amides of other acids do not act as substrates.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Fukatsu, H., Hashimoto, Y., Goda, M., Higashibata, H. and Kobayashi, M.
    Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning.
    Proc. Natl. Acad. Sci. USA 101: 13726-13731 (2004). [PMID: 15358859]

[EC 3.5.1.91 created 2005]