EC 1.1.1.286 - Isocitrate—homoisocitrate dehydrogenase

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IntEnz Enzyme Nomenclature
EC 1.1.1.286

Names

Accepted name:
isocitrate—homoisocitrate dehydrogenase
Other names:
homoisocitrate—isocitrate dehydrogenase
PH1722
Systematic name:
isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating)

Reactions

Cofactors

Comments:

Requres Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00389
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033708
UniProtKB/Swiss-Prot:

References

  1. Miyazaki, K.
    Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of β-decarboxylating dehydrogenase.
    Biochem. Biophys. Res. Commun. 331: 341-346 (2005). [PMID: 15845397]

[EC 1.1.1.286 created 2005]