EC 6.3.2.12 - Dihydrofolate synthase

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ENZYME: 6.3.2.12


ID   6.3.2.12
DE   Dihydrofolate synthase.
AN   7,8-dihydrofolate synthetase.
AN   DHFS.
AN   Dihydrofolate synthetase.
AN   H(2)-folate synthetase.
CA   ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-
CA   dihydropteroylglutamate.
CC   -!- In some bacteria, a single protein catalyzes both this activity and
CC       that of EC 6.3.2.17, the combined activity of which leads to the
CC       formation of the coenzyme polyglutamated tetrahydropteroate
CC       (H(4)PteGlu(n)), i.e. various tetrahydrofolates.
CC   -!- In contrast, the activities are located on separate proteins in most
CC       eukaryotes studied to date.
CC   -!- This enzyme is reponsible for attaching the first glutamate residue
CC       to dihydropteroate to form dihydrofolate and is present only in those
CC       organisms that have the ability to synthesize tetrahydrofolate de
CC       novo, e.g. plants, most bacteria, fungi and protozoa.
DR   F4JYE9    , DHFS_ARATH ;  Q05865    , FOLC_BACSU ;  P57265    , FOLC_BUCAI ;
DR   Q8K9X3    , FOLC_BUCAP ;  Q89AT2    , FOLC_BUCBP ;  P08192    , FOLC_ECOLI ;
DR   P43775    , FOLC_HAEIN ;  I6Y0R5    , FOLC_MYCTU ;  Q9UTD0    , FOLD_SCHPO ;
DR   Q12676    , FOLD_YEAST ;
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