EC - Arogenate dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
arogenate dehydrogenase
Other names:
arogenic dehydrogenase [ambiguous]
cyclohexadienyl dehydrogenase [ambiguous]
pretyrosine dehydrogenase [ambiguous]
L-arogenate:NAD+ oxidoreductase
arogenate dehydrogenase (NAD+)
Systematic name:
L-arogenate:NAD+ oxidoreductase (decarboxylating)



Arogenate dehydrogenases may utilize NAD+ (EC, NADP+ (EC, or both (EC NAD+-specific enzymes have been reported from some bacteria [2] and plants [3]. Some enzymes also possess the activity of EC, prephenate dehydrogenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC51176
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047794
CAS Registry Number: 64295-75-6


  1. Stenmark, S.L., Pierson, D.L., Jensen, R.A. and Glover, G.I.
    Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway.
    Nature 247: 290-292 (1974). [PMID: 4206476]
  2. Byng, G. S., Whitaker, R. J., Gherna, R. L., Jensen, R. A.
    Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae.
    J. Bacteriol. 144: 247-257 (1980). [PMID: 7419490]
  3. Byng, G., Whitaker, R., Flick, C. and Jensen, R.A.
    Enzymology of L-tyrosine biosynthesis in corn (Zea mays).
    Phytochemistry 20: 1289-1292 (1981).
  4. Mayer, E., Waldner-Sander, S., Keller, B., Keller, E., Lingens, F.
    Purification of arogenate dehydrogenase from Phenylobacterium immobile.
    FEBS Lett. 179: 208-212 (1985). [PMID: 3967752]
  5. Lingens, F., Keller, E. and Keller, B.
    Arogenate dehydrogenase from Phenylobacterium immobile.
    Methods Enzymol. 142: 513-518 (1987).
  6. Zamir, L. O., Tiberio, R., Devor, K. A., Sauriol, F., Ahmad, S., Jensen, R. A.
    Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa.
    J. Biol. Chem. 263: 17284-17290 (1988). [PMID: 2972718]

[EC created 1989, modified 2003, modified 2005, modified 2015]