EC - 2,4-dienoyl-CoA reductase (NADPH)

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IntEnz Enzyme Nomenclature


Accepted name:
2,4-dienoyl-CoA reductase (NADPH)
Other names:
4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase
4-enoyl-CoA reductase
4-enoyl-CoA reductase (NADPH2)
Systematic name:
trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase



Best substrates for reduction contain a 2,4-diene structure with a chain-length of 8 or 10.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008670
CAS Registry Number: 82869-38-3
UniProtKB/Swiss-Prot: (14) [show] [UniProt]


  1. Dommes, V., Luster, W., Cvetanovic, M. and Kunau, W.-H.
    Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli.
    Eur. J. Biochem. 125: 335-341 (1982). [PMID: 6749495]
  2. Kunau, W.-H. and Dommes, P.
    Degradation of unsaturated fatty acids. Identification of intermediates in the degradation of cis-4-decenoly-CoA by extracts of beef-liver mitochondria.
    Eur. J. Biochem. 91: 533-544 (1978). [PMID: 729581]

[EC created 1984, modified 1986]