EC - Lactate—malate transhydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
lactate—malate transhydrogenase
Other name:
malate-lactate transhydrogenase
Systematic name:
(S)-lactate:oxaloacetate oxidoreductase



Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This prosthetic group cannot be removed without denaturation of the protein.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050042
CAS Registry Number: 9077-15-0


  1. Allen, S.H.G.
    The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus.
    J. Biol. Chem. 241 : 5266-5275 (1966). [PMID: 4289051]
  2. Allen, S.H.G. and Patil, J.R.
    Studies on the structure and mechanism of action of the malate-lactate transhydrogenase.
    J. Biol. Chem. 247 : 909-916 (1972). [PMID: 4333516]

[EC created 1972]