EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature
EC 1.1.1.197

Names

Accepted name:
15-hydroxyprostaglandin dehydrogenase (NADP+)
Other names:
NADP-dependent 15-hydroxyprostaglandin dehydrogenase
NADP-linked 15-hydroxyprostaglandin dehydrogenase
NADP-specific 15-hydroxyprostaglandin dehydrogenase
type II 15-hydroxyprostaglandin dehydrogenase
Systematic name:
(13E)-(15S)-11α,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase

Reaction

Comments:

Acts on prostaglandins E2, F2α and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047021
CAS Registry Number: 54989-39-8
UniProtKB/Swiss-Prot:

References

  1. Lee, S.-C. and Levine, L.
    Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.
    J. Biol. Chem. 250: 548-552 (1975). [PMID: 234431]
  2. Lee, S.-C., Pong, S.-S., Katzen, D., Wu, K.-Y. and Levine, L.
    Distribution of prostaglandin E 9-ketoreductase and types I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.
    Biochemistry 14: 142-145 (1975). [PMID: 10803247]

[EC 1.1.1.197 created 1984]