EC - Prostaglandin-F synthase

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IntEnz Enzyme Nomenclature


Accepted name:
prostaglandin-F synthase
Other names:
NADPH-dependent prostaglandin D2 11-keto reductase
PGD2 11-ketoreductase
PGF synthetase
PGF2α synthetase
prostaglandin 11-keto reductase
prostaglandin 11-ketoreductase
prostaglandin D2-ketoreductase
prostaglandin F synthase
prostaglandin F synthetase
prostaglandin-D2 11-reductase
reductase, 15-hydroxy-11-oxoprostaglandin
synthetase, prostaglandin F2α
Systematic name:
(5Z,13E)-(15S)-9α,11α,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase



Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00061
Structural data: CSA , EC2PDB
Gene Ontology: GO:0036131 , GO:0047017
CAS Registry Number: 55976-95-9


  1. Reingold, D.F., Kawasaki, A. and Needleman, P.
    A novel prostaglandin 11-keto reductase found in rabbit liver.
    Biochim. Biophys. Acta 659: 179-188 (1981). [PMID: 7248318]
  2. Watanabe, K., Shimizu, T. and Hayaishi, O.
    Enzymatic conversion of prostaglandin-D2 to prostaglandin-F2α in the rat lung.
    Biochem. Int. 2: 603-610 (1981).
  3. Watanabe, K., Yoshida, R., Shimizu, T. and Hayaishi, O.
    Enzymatic formation of prostaglandin F2α from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung.
    J. Biol. Chem. 260: 7035-7041 (1985). [PMID: 3858278]
  4. Wong, P.Y.-K.
    Purification and partial characterization of prostaglandin D2 11-keto reductase in rabbit liver.
    Biochim. Biophys. Acta 659: 169-178 (1981). [PMID: 7248317]
  5. Wong, P.Y.-K.
    Purification of PGD2 11-ketoreductase from rabbit liver.
    Methods Enzymol. 86: 117-125 (1982). [PMID: 7132748]

[EC created 1984, modified 1989, modified 1990]