EC 2.8.2.31 - Petromyzonol sulfotransferase

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IntEnz Enzyme Nomenclature
EC 2.8.2.31

Names

Accepted name:
petromyzonol sulfotransferase
Other name:
PZ-SULT
Systematic name:
3'-phosphoadenylyl-sulfate:5α-cholan-3α,7α,12α,24-tetrol sulfotransferase

Reaction

Comments:

The enzyme from the lamprey Petromyzon marinus can also use the corresponding 3-ketone as a substrate. It is stereoselective (5α-cholane) and regioselective, exhibiting a preference for an hydroxy group at C-24. The enzyme is inactive when allocholic acid, which has a carboxy group at C-24, is used as a substrate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033873

References

  1. Venkatachalam, K.V., Llanos, D.E., Karami, K J. and Malinovskii, V.A.
    Isolation, partial purification, and characterization of a novel petromyzonol sulfotransferase from Petromyzon marinus (lamprey) larval liver.
    J. Lipid Res. 45: 486-495 (2004). [PMID: 14657197]

[EC 2.8.2.31 created 2004]