EC - Vetispiradiene synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
vetispiradiene synthase
Other names:
pemnaspirodiene synthase
vetispiradiene cyclase
vetispiradiene-forming farnesyl pyrophosphate cyclase
Systematic name:
(2E,6E)-farnesyl diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming)



The initial internal cyclization produces the monocyclic intermediate germacrene A.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0034003
CAS Registry Number: 192465-18-2


  1. Back, K. and Chappell, J.
    Cloning and bacterial expression of a sesquiterpene cyclase from Hyoscyamus muticus and its molecular comparison to related terpene cyclases.
    J. Biol. Chem. 270 : 7375-7381 (1995). [PMID: 7706281]
  2. Keller, H., Czernic, P., Ponchet, M., Ducrot, P.H., Back, K., Chappell, J., Ricci, P. and Marco, Y.
    Sesquiterpene cyclase is not a determining factor for elicitor- and pathogen-induced capsidiol accumulation in tobacco.
    Planta 205 : 467-476 (1998).
  3. Mathis, J.R., Back, K., Starks, C., Noel, J., Poulter, C.D. and Chappell, J.
    Pre-steady-state study of recombinant sesquiterpene cyclases.
    Biochemistry 36 : 8340-8348 (1997). [PMID: 9204881]
  4. Yoshioka, H., Yamada, N. and Doke, N.
    cDNA cloning of sesquiterpene cyclase and squalene synthase, and expression of the genes in potato tuber infected with Phytophthora infestans.
    Plant Cell Physiol. 40 : 993-998 (1999). [PMID: 10588069]
  5. Martin, V.J., Yoshikuni, Y. and Keasling, J.D.
    The in vivo synthesis of plant sesquiterpenes by Escherichia coli.
    Biotechnol. Bioeng. 75 : 497-503 (2001). [PMID: 11745124]

[EC created 2004, modified 2011]