EC 3.5.1.90 - Adenosylcobinamide hydrolase

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IntEnz Enzyme Nomenclature
EC 3.5.1.90

Names

Accepted name:
adenosylcobinamide hydrolase
Other names:
AdoCbi amidohydrolase
CbiZ
AdoCbi hydrolase
Systematic name:
adenosylcobinamide amidohydrolase

Reaction

Comments:

Involved in the salvage pathway of cobinamide in archaea. Archaea convert adenosylcobinamide (AdoCbi) into adenosylcobinamide phosphate (AdoCbi-P) in two steps. First, the amidohydrolase activity of CbiZ cleaves off the aminopropanol moiety of AdoCbi yielding adenosylcobyric acid (AdoCby); second, AdoCby is converted into AdoCbi-P by the action of EC 6.3.1.10, adenosylcobinamide-phosphate synthase (CbiB).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043756
CAS Registry Number: 905988-16-1
UniProtKB/Swiss-Prot:

References

  1. Woodson, J.D. and Escalante-Semerena, J.C.
    CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea.
    Proc. Natl. Acad. Sci. USA 101: 3591-3596 (2004). [PMID: 14990804]

[EC 3.5.1.90 created 2004]