EC 1.14.13.84 - 4-hydroxyacetophenone monooxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.13.84

Names

Accepted name:
4-hydroxyacetophenone monooxygenase
Other name:
HAPMO
Systematic name:
(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming)

Reaction

Cofactor

Comments:

Contains FAD. The enzyme from Pseudomonas fluorescens ACB catalyses the conversion of a wide range of acetophenone derivatives. Highest activity occurs with compounds bearing an electron-donating substituent at the para position of the aromatic ring [1]. In the absence of substrate, the enzyme can act as an NADPH oxidase (EC 1.6.3.1).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033767
UniProtKB/Swiss-Prot:

References

  1. Kamerbeek, N.M., Moonen, M.J., Van Der Ven, J.G., Van Berkel, W.J., Fraaije, M.W. and Janssen, D.B.
    4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB. A novel flavoprotein catalyzing Baeyer-Villiger oxidation of aromatic compounds.
    Eur. J. Biochem. 268: 2547-2557 (2001). [PMID: 11322873]
  2. Kamerbeek, N.M., Olsthoorn, A.J., Fraaije, M.W. and Janssen, D.B.
    Substrate specificity and enantioselectivity of 4-hydroxyacetophenone monooxygenase.
    Appl. Environ. Microbiol. 69: 419-426 (2003). [PMID: 12514023]

[EC 1.14.13.84 created 2004]