EC - Homoisocitrate dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
homoisocitrate dehydrogenase
Other names:
(−)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)
2-hydroxy-3-carboxyadipate dehydrogenase
3-carboxy-2-hydroxyadipate dehydrogenase
3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)
homoisocitric dehydrogenase
Systematic name:
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)



Forms part of the lysine biosynthesis pathway in fungi [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00389
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047046
CAS Registry Number: 37250-23-0


  1. Strassman, M. and Ceci, L.N.
    Enzymatic formation of α-ketoadipic acid from homoisocitric acid.
    J. Biol. Chem. 240: 4357-4361 (1965). [PMID: 4284830]
  2. Rowley, B. and Tucci, A.F.
    Homoisocitric dehydrogenase from yeast.
    Arch. Biochem. Biophys. 141: 499-510 (1970). [PMID: 4395693]
  3. Zabriskie, T.M. and Jackson, M.D.
    Lysine biosynthesis and metabolism in fungi.
    Nat. Prod. Rep. 17: 85-97 (2000). [PMID: 10714900]

[EC created 1972 (EC created 1976, incorporated 2004)]