EC - Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)

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IntEnz Enzyme Nomenclature


Accepted name:
hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
Other name:
Systematic name:
hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)



This step in the aerobic biosynthesis of cobalamin generates hydrogenobyrinic acid a,c-diamide, the substrate required by EC, cobaltochelatase, which adds cobalt to the macrocycle.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043802
CAS Registry Number: 132053-22-6
UniProtKB/Swiss-Prot: (17) [show] [UniProt]


  1. Debussche, L., Thibaut, D., Cameron, B., Crouzet, J. and Blanche, F.
    Purification and characterization of cobyrinic acid a,c-diamide synthase from Pseudomonas denitrificans.
    J. Bacteriol. 172: 6239-6244 (1990). [PMID: 2172209]
  2. Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C.
    The biosynthesis of adenosylcobalamin (vitamin B12).
    Nat. Prod. Rep. 19: 390-412 (2002). [PMID: 12195810]

[EC created 2004]