EC - Inositol-hexakisphosphate kinase

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IntEnz Enzyme Nomenclature


Accepted name:
inositol-hexakisphosphate kinase
Other names:
ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
Systematic name:
ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase



Three mammalian isoforms are known to exist.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052723 , GO:0052724 , GO:0000832 , GO:0000827 , GO:0050517
CAS Registry Number: 176898-37-6
UniProtKB/Swiss-Prot: (42) [show] [UniProt]


  1. Saiardi, A., Erdjument-Bromage, H., Snowman, A.M., Tempst, P. and Snyder, S.H.
    Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.
    Curr. Biol. 9 : 1323-1326 (1999). [PMID: 10574768]
  2. Schell, M.J., Letcher, A.J., Brearley, C.A., Biber, J., Murer, H. and Irvine, R.F.
    PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase.
    FEBS Lett. 461 : 169-172 (1999). [PMID: 10567691]
  3. Albert, C., Safrany, S.T., Bembenek, M.E., Reddy, K.M., Reddy, K.K., Falck, J.-R., Bröcker, M., Shears, S.B. and Mayr, G.W.
    Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.
    Biochem. J. 327 : 553-560 (1997). [PMID: 9359429]
  4. Lin, H., Fridy, P. C., Ribeiro, A. A., Choi, J. H., Barma, D. K., Vogel, G., Falck, J. R., Shears, S. B., York, J. D., Mayr, G. W.
    Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.
    J. Biol. Chem. 284 : 1863-1872 (2009). [PMID: 18981179]
  5. Wang, H., Falck, J. R., Hall, T. M., Shears, S. B.
    Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
    Nat. Chem. Biol. 8 : 111-116 (2012). [PMID: 22119861]

[EC created 2002 as EC, transferred 2003 to EC, modified 2013]