EC 3.8.1.11 - 2-haloacid dehalogenase (configuration-retaining)

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IntEnz Enzyme Nomenclature
EC 3.8.1.11

Names

Accepted name:
2-haloacid dehalogenase (configuration-retaining)
Other names:
2-haloalkanoic acid dehalogenase
2-haloalkanoid acid halidohydrolase
DL-2-haloacid dehalogenase
DL-DEXr
Systematic name:
(S)-2-haloacid dehalogenase (configuration-retaining)

Reactions

Comments:

Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids, respectively, with retention of configuration at C-2. (see also EC 3.8.1.2, (S)-2-haloacid dehalogenase, EC 3.8.1.9, (R)-2-haloacid dehalogenase and EC 3.8.1.10, 2-haloacid dehalogenase (configuration-inverting)).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033977

References

  1. Weightman, A.J., Weightman, A.L. and Slater, J.H.
    Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas P3: evidence for two different dehalogenation mechanisms.
    J. Gen. Microbiol. 128: 1755-1762 (1982). [PMID: 7142958]
  2. Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N.
    Bacterial 2-haloacid dehalogenases: Structures and catalytic properties.
    Pure Appl. Chem. 68: 2097-2103 (1996).

[EC 3.8.1.11 created 2003]