EC - Leucoanthocyanidin reductase

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IntEnz Enzyme Nomenclature


Accepted name:
leucoanthocyanidin reductase
Other name:
leucocyanidin reductase
Systematic name:
(2R,3S)-catechin:NADP+ 4-oxidoreductase



The enzyme catalyses the synthesis of catechin, catechin-4β-ol (leucocyanidin) and the related flavan-3-ols afzelechin and gallocatechin, which are initiating monomers in the synthesis of plant polymeric proanthocyanidins or condensed tannins. While 2,3-trans-3,4-cis-leucocyanidin is the preferred flavan-3,4-diol substrate, 2,3-trans-3,4-cis-leucodelphinidin and 2,3-trans-3, 4-cis-leucopelargonidin can also act as substrates, but more slowly. NADH can replace NADPH but is oxidized more slowly.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033788


  1. Tanner, G.J. and Kristiansen, K.N.
    Synthesis of 3,4-cis-[3H]leucocyanidin and enzymatic reduction to catechin.
    Anal. Biochem. 209: 274-277 (1993). [PMID: 8470799]
  2. Tanner, G.J., Francki, K.T., Abrahams, S., Watson, J.M., Larkin, P.J. and Ashton, A.R.
    Proanthocyanidin biosynthesis in plants: Purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNA.
    J. Biol. Chem. 278: 31647-31656 (2003). [PMID: 12788945]

[EC created 2003]