EC - Aminocyclopropanecarboxylate oxidase

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IntEnz Enzyme Nomenclature


Accepted name:
aminocyclopropanecarboxylate oxidase
Other names:
ACC oxidase
ethylene-forming enzyme
1-aminocyclopropane-1-carboxylate oxidase
Systematic name:
1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)




A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethylene has signalling functions such as stimulation of fruit-ripening.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC51471
Structural data: CSA , EC2PDB
Gene Ontology: GO:0009815
UniProtKB/Swiss-Prot: (31) [show] [UniProt]


  1. Zhang, Z.H., Schofield, C.J., Baldwin, J.E., Thomas, P. and John, P.
    Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli.
    Biochem. J. 307 : 77-85 (1995). [PMID: 7717997]
  2. Zhang, Z.H., Barlow, J.N., Baldwin, J.E. and Schofield, C.J.
    Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase.
    Biochemistry 36 : 15999-16007 (1997). [PMID: 9398335]
  3. Pirrung, M.C.
    Ethylene biosynthesis from 1-aminocyclopropanecarboxylic acid.
    Acc. Chem. Res. 32 : 711-718 (1999).
  4. Charng, Y., Chou, S.J., Jiaang, W.T., Chen, S.T. and Yang, S.F.
    The catalytic mechanism of 1-aminocyclopropane-1-carboxylic acid oxidase.
    Arch. Biochem. Biophys. 385 : 179-185 (2001). [PMID: 11361015]
  5. Thrower, J.S., Blalock, R. and Klinman, J.P.
    Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase.
    Biochemistry 40 : 9717-9724 (2001). [PMID: 11583172]

[EC created 2003]