EC - Isochorismate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
isochorismate synthase
Other names:
isochorismate synthetase
isochorismate mutase
Systematic name:
isochorismate hydroxymutase




Requires Mg2+. The reaction is reversible.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008909
CAS Registry Number: 37318-53-9
UniProtKB/Swiss-Prot: (19) [show] [UniProt]


  1. Young, I.G. and Gibson, F.
    Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli.
    Biochim. Biophys. Acta 177: 401-411 (1969). [PMID: 4306838]
  2. van Tegelen, L.J., Moreno, P.R., Croes, A.F., Verpoorte, R. and Wullems, G.J.
    Purification and cDNA cloning of isochorismate synthase from elicited cell cultures of Catharanthus roseus.
    Plant Physiol. 119: 705-712 (1999). [PMID: 9952467]
  3. Dahm, C., Müller, R., Schulte, G., Schmidt, K. and Leistner, E.
    The role of isochorismate hydroxymutase genes entC and menF in enterobactin and menaquinone biosynthesis in Escherichia coli.
    Biochim. Biophys. Acta 1425: 377-386 (1998). [PMID: 9795253]
  4. Daruwala, R., Kwon, O., Meganathan, R. and Hudspeth, M.E.S.
    A new isochorismate synthase specifically involved in menaquinone (vitamin K2) biosynthesis encoded by the menF gene.
    FEMS Microbiol. Lett. 140: 159-163 (1996). [PMID: 8764478]

[EC created 1972 as EC, transferred 2003 to EC]