EC 2.4.1.228 - Lactosylceramide 4-α-galactosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.228

Names

Accepted name:
lactosylceramide 4-α-galactosyltransferase
Other names:
Galβ1-4Glcβ1-Cer α1,4-galactosyltransferase
globotriaosylceramide/CD77 synthase
histo-blood group Pk UDP-galactose
UDP-galactose:lactosylceramide 4II-α-D-galactosyltransferase
UDP-galactose:β-D-galactosyl-(1→4)-D-glucosyl-(1↔1)-ceramide 4II-α-D-galactosyltransferase
Systematic name:
UDP-α-D-galactose:β-D-galactosyl-(1→4)-D-glucosyl-(1↔1)-ceramide 4II-α-D-galactosyltransferase

Reaction

Comments:

For explanation of superscript II in systematic name, see 2-Carb-37.2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050512
CAS Registry Number: 52725-57-2
UniProtKB/Swiss-Prot:

References

  1. Bailly, P., Piller, F., Cartron, J.P., Leroy, Y. and Fournet, B.
    Identification of UDP-galactose: lactose (lactosylceramide) α-4 and β-3 galactosyltransferases in human kidney.
    Biochem. Biophys. Res. Commun. 141: 84-91 (1986). [PMID: 3099784]
  2. Steffensen, R., Carlier, K., Wiels, J., Levery, S.B., Stroud, M., Cedergren, B., Nilsson Sojka, B., Bennett, E.P., Jersild, C. and Clausen, H.
    Cloning and expression of the histo-blood group Pk UDP-galactose: Galβ1-4Glcβ1-Cer α1,4-galactosyltransferase. Molecular genetic basis of the p phenotype.
    J. Biol. Chem. 275: 16723-16729 (2000). [PMID: 10747952]
  3. Kojima, Y., Fukumoto, S., Furukawa, K., Okajima, T., Wiels, J., Yokoyama, K., Suzuki, Y., Urano, T., Ohta, M. and Furukawa, K.
    Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids.
    J. Biol. Chem. 275: 15152-15156 (2000). [PMID: 10748143]

[EC 2.4.1.228 created 2002]