EC 2.4.1.227 - Undecaprenyldiphospho-muramoylpentapeptide β-N-acetylglucosaminyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.227

Names

Accepted name:
undecaprenyldiphospho-muramoylpentapeptide β-N-acetylglucosaminyltransferase
Other names:
MurG transferase
undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
UDP-N-acetylglucosamine—N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
UDP-N-acetyl-D-glucosamine:N-acetyl-α-D-muramyl(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol β-1,4-N-acetylglucosaminlytransferase
UDP-N-acetyl-D-glucosamine:N-acetyl-α-D-muramyl(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol 4-β-N-acetylglucosaminlytransferase
Systematic name:
UDP-N-acetyl-α-D-glucosamine:N-acetyl-α-D-muramyl(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol 4-β-N-acetylglucosaminlytransferase (configuration-inverting)

Reaction

Comments:

The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-centre, as it is in Gram-negative and some Gram-positive organisms. The undecaprenol involved is ditrans,octacis-undecaprenol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0051991 , GO:0050511
CAS Registry Number: 60976-26-3
UniProtKB/Swiss-Prot: (688) [show] [UniProt]

References

  1. van Heijenoort, J.
    Recent advances in the formation of the bacterial peptidoglycan monomer unit.
    Nat. Prod. Rep. 18 : 503-519 (2001). [PMID: 11699883]

[EC 2.4.1.227 created 2002]