EC - 3-hydroxybutyrate dehydrogenase

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IntEnz Enzyme Nomenclature


Accepted name:
3-hydroxybutyrate dehydrogenase
Other names:
3-D-hydroxybutyrate dehydrogenase
β-hydroxybutyrate dehydrogenase
β-hydroxybutyric acid dehydrogenase
β-hydroxybutyric dehydrogenase
D-(-)-3-hydroxybutyrate dehydrogenase
D-3-hydroxybutyrate dehydrogenase
D-β-hydroxybutyrate dehydrogenase
NAD-β-hydroxybutyrate dehydrogenase
hydroxybutyrate oxidoreductase
Systematic name:
(R)-3-hydroxybutanoate:NAD+ oxidoreductase



Also oxidizes other 3-hydroxymonocarboxylic acids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003858
CAS Registry Number: 9028-38-0
UniProtKB/Swiss-Prot: (15) [show] [UniProt]


  1. Bergmeyer, H.-U., Gawehn, K., Klotzsch, H., Krebs, H.A. and Williamson, D.H.
    Purification and properties of crystalline 3-hydroxybutyrate dehydrogenase from Rhodopseudomonas spheroides.
    Biochem. J. 102: 423-431 (1967). [PMID: 4291491]
  2. Delafield, F.P., Cooksey, K.E. and Doudoroff, M.
    β-Hydroxybutyric dehydrogenase and dimer hydrolase of Pseudomonas lemoignei.
    J. Biol. Chem. 240: 4023-4028 (1965). [PMID: 4954074]
  3. Lehninger, A.L., Sudduth, H.C. and Wise, J.B.
    D-β-Hydroxybutyric dehydrogenase of mitochondria.
    J. Biol. Chem. 235: 2450-2455 (1960).

[EC created 1961]