EC 2.4.1.214 - Glycoprotein 3-α-L-fucosyltransferase

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ENZYME: 2.4.1.214


ID   2.4.1.214
DE   Glycoprotein 3-alpha-L-fucosyltransferase.
AN   GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-
AN   peptide) alpha-1->3-fucosyltransferase.
AN   GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase.
AN   GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase.
CA   GDP-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-
CA   mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-
CA   (1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-
CA   acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D-
CA   glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-
CA   glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-
CA   acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->3))-N-acetyl-beta-
CA   D-glucosaminyl)asparagine.
CF   Mn(2+).
CC   -!- The enzyme transfers to N-linked oligosaccharide structures
CC       (N-glycans), generally with a specificity for N-glycans with one
CC       unsubstituted non-reducing terminal GlcNAc residue.
CC   -!- This enzyme catalyzes a reaction similar to that of EC 2.4.1.68,
CC       but transferring the L-fucosyl group from GDP-beta-L-fucose to form
CC       an alpha-1,3-linkage rather than an alpha-1,6-linkage.
CC   -!- The N-glycan products of this enzyme are present in plants, insects
CC       and some other invertebrates (e.g., Schistosoma, Haemonchus,
CC       Lymnaea).
DR   Q9VUL9    , FUCTA_DROME;  Q9LJK1    , FUT11_ARATH;  G5EDR5    , FUTA_CAEEL ;
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