EC - Trypanothione-disulfide reductase

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IntEnz Enzyme Nomenclature


Accepted name:
trypanothione-disulfide reductase
Other names:
NADPH2:trypanothione oxidoreductase
trypanothione reductase
NADPH:trypanothione oxidoreductase
N1,N8-bis(glutathionyl)spermidine reductase
Systematic name:
trypanothione:NADP+ oxidoreductase




Trypanothione disulfide is the oxidized form of N1,N8-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. The enzyme from Crithidia fasciculata is a flavoprotein (FAD), whose activity is dependent on a redox-active cystine at the active centre (cf. EC, glutathione-disulfide reductase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00073
Structural data: CSA , EC2PDB
Gene Ontology: GO:0015042
CAS Registry Number: 102210-35-5


  1. Shames, S.L., Fairlamb, A.H., Cerami, A. and Walsh, C.T.
    Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases.
    Biochemistry 25: 3519-3526 (1986).
  2. Marsh, I.R. and Bradley, M.
    Substrate specificity of trypanothione reductase.
    Eur. J. Biochem. 243: 690-694 (1977). [PMID: 9057833]
  3. Cunningham, M.L. and Fairlamb, A.H.
    Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials.
    Eur. J. Biochem. 230: 460-468 (1995). [PMID: 7607216]

[EC created 1989 as EC, transferred 2002 to EC]